Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine Molecular Psychiatry Exploring the Evidence of N Acetyl Cysteine (NAC) for Mood Disorders Psychopharmacology Institute The distance between a compound demonstrating efficacy in preclinical research and that compound appearing in a physician's standard toolkit can span a generation. The mechanisms by which NAC addresses oxidative stress, glutamate Glutathione: Physiological and Clinical Relevance Restorative Medicine Plasma glutathione suggests oxidative stress is equally present in early and lateonset bipolar disorder Singh 2019 Bipolar Disorders Wiley Online Library