g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Tylenol depletes glutathione levels Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Serotonin Deficiency Exacerbates Acetaminophen Induced Liver Toxicity In Mice Scientific Reports Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health