Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential ScienceDirect Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums