Can Marijuana Use Prevent You From Giving Blood? Smoking (or vaping) doesn't affect your ability to donate blood. Help us bust this myth by sharing our post. Can You Donate Blood If You Smoke? Cannabis, Nicotine, and More Severe bleeding linked to synthetic cannabinoid use Texas Poison Center Network Yes, you can donate blood if you smoke or consume cannabis. The recipient of the blood will not get high, another common MYTH. All donors go through the same health