Glucose 6 Phosphate Dehydrogenase Deficiency Symptoms, Pathophysiology, Diagnosis and Treatment Glucose 6 phosphate dehydrogenase (G6PD) deficiency X linked recessive Xq28 is not true recessive as heterozygotes can express the trait; G6PD > No NADPH > No RBC glutathione protection > free radical damage hemolysis A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway Nature Chemical Biology G6PD Deficiency Causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Is Glutathione Safe for G6PD Deficiency? Understanding the Antioxidant Connection Cymbiotika CYMBIOTIKA